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1. Upham JW, Holt, J, Baron Hay MJ, Yobuhara A, Hales, BJ, Thomas WR, et al. Inhalant allergen specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium. Clin Exp Allergy 1995; 25: 634-42. Working Group on Environmental Allergens and Asthma, American Academy of Allergy, Asthma and Immunology. Environmental allergen avoidance in allergic asthma. In: Academy news. Milwaukee: American Academy of Allergy Asthma and Immunology. 1998; Feb: 9-11. 3. Platts-Mills TA, Vervloet D, Thomas WR, Aalberse RC, Chapman MD. Indoor allergens and asthma: report of the third international workshop. J Allergy Clin Immunol 1997; 100 6 pt 1 ; S2-24. 4. Holt PG, O'Keeffe PO, Holt BJ, Upham JW, Baron Hay MJ, Suphioglu C, et al. T-cell "priming" against environmental allergens in human neonates: sequential deletion of food antigen specificities during infancy with concomitant expansion of responses to ambiguous inhalant allergens. Pediatr Allergy Immunol 1995; 6: 85-90. Warner JA, Jones AC, Miles EA, Colwell BM, Warner JO. Prenatal origins of asthma and allergy. Ciba Found Symp 1997; 206: 220-8. Holt PG. Is immunization against allergic sensitization a realistic prospect for the future? Allergy Clin Immunol Int 1996; 8: 169-71. Munir AK, Kjellman NI, Bjrkstn B. Exposure to indoor allergens in early infancy and sensitization. J Allergy Clin Immunol 1997; 100: 177-81. Burr ML, Merrett TG, Dunstan FD, Maguire MJ. The development of allergy in high risk children. Clin Exp Allergy 1997; 27: 1247-53. Hattevig G, Kjellman B, Bjrkstn B. Clinical symptoms and IgE responses to common food proteins and inhalants in the first 7 years of life. Clin Allergy 1987; 17: 571-8. Zeiger RS, Heller S. The development and prediction of atopy in high risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin Immunol 1995; 95: 1179-90. Sigurs N, Hattevig G, Kjellman B, Kkjellman NI, Nilsson L, Bjrkstn B. Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 415 years. J Allergy Clin Immunol 1994; 94: 757-63. Lombardi E, Morgan WJ, Wright AL, Stein RT, Holberg CJ. Martinez FD. Cold air challenge at age 6 and subsequent incidence of asthma. A longitudinal study. J Respir Crit Care Med 1997; 156: 1863-9. Ernst P, Fitzgerald JM, Spier S. Canadian Asthma Conference summary of recommendations. Can Respir J 1996; 3 2 ; : 89-100. 14. Rosenstreich DL, Eggleston P, Katten M, Baker D. Slavin RG, Gergen P, et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med 1997; 336: 1356-63. Squillace SP, Sporik RB, Rakes G, Couture N, Lawrence A, Merriam S, et al. Sensitization to dust-mites as a dominant risk factor for asthma among adolescents living in central Virginia. Multiple regression analysis of a population based study. J Respir Crit Care Med 1997; 156: 1760-4. Van der Heide S, DeMonchy JG, De Vries K, Dubois AE, Kauffman HF. Seasonal differences in airway hyper-responsiveness in asthmatic patients: relationship with allergen exposure and sensitization to house dust mites. Clin Exp Allergy 1997; 27: 627-33. Ronborg SM, Mosbeck H, Poulsen LK. Exposure chamber for allergen challenge. A placebo-controlled, double-blind trial in house-dust-mite asthma. Allergy 1997; 52: 821-8. Sarpong SB, Karrison T. Sensitization to indoor allergens and the risk for asthma hospitalization in children. Ann Allergy Asthma Immunol 1997; 79: 455-9. Hayden ML, Perzanowski M, Matheson L, Scott P. Call RS, Platts-Mills TA. Dust mite allergen avoidance in the treatment of hospitalized children with asthma. Ann Allergy Asthma Immunol 1997; 79: 437-42. Delfino RJ, Zeiger RS, Seltzer JM, Street DH, Matteucci RM, Anderson PR, et al. The effect of outdoor fungal spore concentrations on daily asthma severity. Environ Health Perspect 1997; 105: 622-35. Hilterman TJ, de Bruijne CR, Stolk J, Zwinderman AM, Spieksma FT, Roemer W, et al. Effects of photochemical air pollution and allergen exposure on upper respiratory tract inflammation in asthmatics. J Respir Crit Care Med 1997; 156: 1765-72. Johnston SL. Influence of viral and bacterial respiratory infections on exacerbations and symptom severity in childhood asthma. Pediatr Pulmonol 1997; 16 Suppl ; : 88-9. 23. Rager KJ, Langland JO, Jacobs BL, Proud D, Marsh DG, Imani F. Activation of antiviral protein kinase leads to immunoglobulin E class switching in human B cells. J Virol 1998; 72: 1171-6. 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In work previously reported + ; -12-methyltetradecanoic and 13-methyltetradecanoic acids were isolated from mutton fat Hansen, Shorland & Cooke, 1953 ; , and from butterfat Hansen, Shorland & Cooke, 1954a ; , while n-pentadecanoic acid was isolated from mutton fat Hansen, Shorland & Cooke, 1954b ; . As, however, the isolation procedure in each case involved hydrogenation, it was not established with certainty that these acids were originally present in the fats as saturated constituents. In this paper it is shown that without hydrogenation, and by use of a highly efficient fractionating column, two fractions were obtained from butterfat, the first of which contained mainly a mixture of the methyl esters of + ; -12-methyltetradecanoic and 13-methyltetradecanoic acids and the second consisted essentially of methyl n-pentadecanoate and imovane. Allowed Charge The maximum amount the Plan determines is payable for a covered expense. For this Plan the Allowed Charge will be the contracted reimbursement rate including any applicable sales tax. When this Plan is secondary to other insurance coverage, the Allowed Charge will be the amount allowed but not covered by the other plan subject to the coverage provisions of this Plan. Brand Name Typically, this means a drug manufactured and marketed under a trademark, or name by a specific drug manufacturer. For purposes of pricing, drug classification e.g., brand vs. generic ; will be established by a nationally recognized drug pricing and classification source. Compound Medicine A medication mixed for a specific Plan Participant and not available commercially. To be eligible for reimbursement, a Compound Medication must contain at least one Legend Drug that has been assigned a national drug code NDC ; number, requiring a Doctor's Order to dispense, and eligible for coverage under this Plan. Coinsurance Is a sharing mechanism of the cost of health care and is expressed as a percentage of the Allowed Charge that will be paid by You and the balance paid by the Plan. Copayment A specified amount that You are required to pay for each quantity or supply of prescription medication that is purchased. Copayment Coinsurance Maximum The maximum combined total for a Plan Participant on the Coinsurance and Copayments for Generic, Preferred and Special Case Medications. Coinsurance for Non Preferred Drug does not accumulate toward the Copayment Coinsurance Maximum. Drug Override A feature that allows Plan Participants who meet specific criteria outlined in the Plan to receive Non Preferred Drugs at the Preferred Drug Coinsurance level. Your Coinsurance for Non Preferred Drugs with a Drug Override do not accumulate toward the Copayment Coinsurance Maximum.

Int j clin pharmacol ther toxicol 31 : 223– 22 pubmed namba h, iyo m, fukushi k, shinotoh h, nagatsuka s, suhara t et al 1999.

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